Methyl 4-(bromomethyl)benzoate → Methyl-4-[(4-{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Phenoxy) Methyl]Benzoate

HRID 2104678Notes

Reaction equation

HRID 2104678 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:29]=[CH:30][CH:31]=1)[O:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:32]([F:35])([F:34])[F:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:36][O:37][C:38](=[O:47])[C:39]1[CH:44]=[CH:43][C:42]([CH2:45]Br)=[CH:41][CH:40]=1>>[CH3:36][O:37][C:38](=[O:47])[C:39]1[CH:44]=[CH:43][C:42]([CH2:45][O:28][C:25]2[CH:26]=[CH:27][C:22]([O:21][C:20]3[CH:29]=[CH:30][CH:31]=[C:18]([C:17]4[C:16]5[C:11](=[C:12]([C:32]([F:35])([F:33])[F:34])[CH:13]=[CH:14][CH:15]=5)[N:10]=[CH:9][C:8]=4[CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH:19]=3)=[CH:23][CH:24]=2)=[CH:41][CH:40]=1

Participants

3

Reactant 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 16718799HCID 16718799, compound

Product 1

HCID 66914534Methyl-4-[(4-{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Phenoxy) Methyl]Benzoate

Procedure

The title compound was prepared from 4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]-phen-oxy}phenol (0.1 g, 0.0002 mole) and 4-Bromomethyl-benzoic acid methyl ester (0.057 g, 0.00024 mole) following the procedure of Example 478: MS (ESI) [M+H]+), 620.0.

Sources & evidence

ORD record
ord-e843122475824e3fbc8513f1650118c7
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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