Methyl 4-(bromomethyl)benzoate → 4-[(4-{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Phenoxy)Methyl]Benzoic Acid

HRID 2104679Notes

Reaction equation

HRID 2104679 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:29]=[CH:30][CH:31]=1)[O:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:32]([F:35])([F:34])[F:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:37][C:38](=[O:47])[C:39]1[CH:44]=[CH:43][C:42]([CH2:45]Br)=[CH:41][CH:40]=1>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:29]=[CH:30][CH:31]=1)[O:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:45][C:42]3[CH:43]=[CH:44][C:39]([C:38]([OH:47])=[O:37])=[CH:40][CH:41]=3)=[CH:24][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:32]([F:35])([F:33])[F:34])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 16718799HCID 16718799, compound

Product 1

HCID 669136604-[(4-{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Phenoxy)Methyl]Benzoic Acid

Procedure

The title compound was prepared from 4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]-phen-oxy}phenol (0.1 g, 0.0002 mole) and 4-Bromomethyl-benzoic acid methyl ester (0.057 g, 0.00024 mole) with subsequent hydrolysis following the procedure of Example 515: MS (ES) m/z 603.9; HRMS: calcd for C37H26F3NO4+H+, 606.18867; found (ESI, [M+H]+), 606.1894.

Sources & evidence

ORD record
ord-86b4e21e2e364da4b3683614de439df5
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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