Methyl bromoacetate → (4-{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Phenoxy)Acetic Acid

HRID 2104680Notes

Reaction equation

HRID 2104680 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:29]=[CH:30][CH:31]=1)[O:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:32]([F:35])([F:34])[F:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:37][C:38](=[O:41])[CH2:39]Br>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:29]=[CH:30][CH:31]=1)[O:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:39][C:38]([OH:41])=[O:37])=[CH:24][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:32]([F:35])([F:33])[F:34])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 60984Methyl bromoacetateHCID 16718799HCID 16718799, compound

Product 1

HCID 66914495(4-{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Phenoxy)Acetic Acid

Procedure

The title compound was prepared from 4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]-phen-oxy}phenol and Bromo-acetic acid methyl ester with subsequent hydrolysis following the procedure of Example 515: MS (ES) m/z 527.9.

Sources & evidence

ORD record
ord-6da6783d20404018ac6645cc6077e980
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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