Methyl 2-(4-(bromomethyl)phenyl)-2-methylpropanoate → 2-[4-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Methyl)Phenyl]-2-Methylpropanoic Acid

HRID 2104710Notes

Reaction equation

HRID 2104710 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:30][C:31](=[O:43])[C:32]([C:35]1[CH:40]=[CH:39][C:38]([CH2:41]Br)=[CH:37][CH:36]=1)([CH3:34])[CH3:33]>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=1)[O:24][CH2:41][C:38]1[CH:37]=[CH:36][C:35]([C:32]([CH3:34])([CH3:33])[C:31]([OH:43])=[O:30])=[CH:40][CH:39]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:26])[F:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 18423131Methyl 2-(4-(bromomethyl)phenyl)-2-methylpropanoateHCID 536307553-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenol

Product 1

HCID 167187502-[4-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Methyl)Phenyl]-2-Methylpropanoic Acid

Procedure

Prepared using the procedure in Example 56 except using 3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenol and 2-(4-Bromomethyl-phenyl)-2-methyl-propionic acid methyl ester as the halide. MS (ESI) m/z 556.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ebc0ccc421764deaaa783b2720118751
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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