3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenol → 2-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Methyl)Terephthalonitrile

HRID 2104712Notes

Reaction equation

HRID 2104712 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29]([C:31]1[CH:38]=[CH:37][C:36]([C:39]#[N:40])=[CH:35][C:32]=1[CH2:33]Br)#[N:30]>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=1)[O:24][CH2:33][C:32]1[CH:35]=[C:36]([C:39]#[N:40])[CH:37]=[CH:38][C:31]=1[C:29]#[N:30])=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:26])[F:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 536307553-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenolHCID 865987652,5 Dicyanobenzylbromide

Product 1

HCID 669137012-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenoxy}Methyl)Terephthalonitrile

Procedure

The title compound was prepared from 3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenol and 2,5 dicyanobenzylbromide as in the procedure of Example 43. MS (ESI) m/z 520.

Sources & evidence

ORD record
ord-c6a145f59f2545e49ce03681eba69c4d
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

Loading…