Hydrochloric Acid → 7-Bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-amine

HRID 210472Notes

Reaction equation

HRID 210472 reaction equation
[Br:4][c:5]1[cH:6][c:7]2[c:17]([cH:18][cH:19]1)[O:16][c:10]1[c:9]([cH:14][c:13]([Cl:15])[n:12][cH:11]1)[C:8]21[N:20]=[C:21]([NH:25][C:26](=[O:27])[c:28]2[cH:29][cH:30][c:31]([N+:32]([O-:33])=[O:34])[cH:35][cH:36]2)[S:22][CH2:23][CH2:24]1.[CH3:37][OH:38].[ClH:3].[Na+:2].[OH-:1].[OH2:39]>>[Br:4][c:5]1[cH:6][c:7]2[c:17]([cH:18][cH:19]1)[O:16][c:10]1[c:9]([cH:14][c:13]([Cl:15])[n:12][cH:11]1)[C:8]21[N:20]=[C:21]([NH2:25])[S:22][CH2:23][CH2:24]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 86658376N-(7'-bromo-3'-chlorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-2-yl)-4-nitrobenzamide

Product 1

HCID 584660017-Bromo-3-chloro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]thiazin]-2'-amine

Sources & evidence

ORD record
ord-53ba32bd9b26499aa65dd14e7766b9aa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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