3-Aminophenylboronic acid → 4-(3-{[3-Cyano-8-(Trifluoromethyl)Quinolin-4-yl]Amino}Phenyl)-8-(Trifluoromethyl)Quinoline-3-Carbonitrile
Reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]#[N:17].[NH2:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][CH:24]=1>>[C:16]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[NH:18][C:19]1[CH:20]=[C:21]([C:2]3[C:11]4[C:6](=[C:7]([C:12]([F:14])([F:13])[F:15])[CH:8]=[CH:9][CH:10]=4)[N:5]=[CH:4][C:3]=3[C:16]#[N:17])[CH:22]=[CH:23][CH:24]=1)=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]([F:15])([F:14])[F:13])#[N:17]Participants
3
Procedure
The title compound was prepared from 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile and 3-aminophenylboronic acid according to the procedure of Example 1 as a side product. MS (ES) m/z 531.8.
Sources & evidence
- ORD record
- ord-0f90929d490c4fab8c747eebaf052e1b
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07576215B2
Reaction notes
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