2-Thiophenecarboxaldehyde → {3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}(2-Thienylmethyl)Amine

HRID 2104780Notes

Reaction equation

HRID 2104780 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:29]1[CH:33]=[CH:32][CH:31]=[C:30]1[CH:34]=O>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH:24][CH2:34][C:30]3[S:29][CH:33]=[CH:32][CH:31]=3)[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:26])[F:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 73642-ThiophenecarboxaldehydeHCID 112342973-(3-Benzyl-8-trifluoromethyl-quinolin-4-yl)-phenylamine

Product 1

HCID 66914494{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}(2-Thienylmethyl)Amine

Procedure

The title compound was prepared from {3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine and thiophene-2-carbaldehyde according to the procedure of Example 66. MS (ES) m/z 475.2.

Sources & evidence

ORD record
ord-5c7c9a9456154dea9a3c873e077a1b5c
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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