Loxoprofen Impurity 18 → HCID 66913725, compound

HRID 2104860Notes

Reaction equation

HRID 2104860 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([CH3:12])=[C:7]2[C:13]1[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=1.C[O:21][C:22](=[O:33])[CH:23]([C:25]1[CH:30]=[CH:29][C:28]([CH2:31]Br)=[CH:27][CH:26]=1)[CH3:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([CH3:12])=[C:7]2[C:13]1[CH:14]=[C:15]([CH:16]=[CH:17][CH:18]=1)[O:19][CH2:31][C:28]1[CH:27]=[CH:26][C:25]([C@H:23]([CH3:24])[C:22]([OH:33])=[O:21])=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 11242311Loxoprofen Impurity 18HCID 534119713-(8-Chloro-3-methylquinolin-4-yl)phenol

Product 1

HCID 66913725HCID 66913725, compound

Procedure

This compound was prepared according to the procedure of example 41, substituting 3-(8-chloro-3-methyl-quinolin-4-yl)-phenol and 2-(4-bromomethyl-phenyl)-propionic acid methyl ester. Purification by supercritical fluid chromatography (MeOH/CO2). Electronic circular dichroism CD λmax=−4 mdeg @ 225 nm (EtOH). MS (ESI) m/z 432.

Workup

  1. customThis compound was prepared
  2. customPurification by supercritical fluid chromatography (MeOH/CO2)

Sources & evidence

ORD record
ord-b6ee1b39228a4a888d9f6677deb6e759
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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