反应详情

3-phenyl-1,2,4-triazole-5-thiol (1.80 g, 10.2 mmol) and Raney Ni (rinsed with EtOH 3×, 3 g) in 30 mL EtOH was refluxed for 1.5 h. The mixture was filtered and concentrated. The crude yellow oil was redissolved in EtOAc and filtered through 1″ SiO2, then concentrated to afford 1.32 g of Intermediate 17.1 as a white crystalline solid.

1. filtrationThe mixture was filtered
2. concentrationconcentrated
3. dissolutionThe crude yellow oil was redissolved in EtOAc
4. filtrationfiltered through 1″ SiO2
5. concentrationconcentrated