HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-((4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)-N'-acetoxybenzamidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 4-((4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)-N'-hydroxybenzamidine | HCID 86607935 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-((4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)-N'-acetoxybenzamidine | HCID 86760938 | — |
Reaction Steps
To a suspension of Intermediate 66.1 in 20 mL EtOAc, was added 0.5 mL Ac2O. The reaction mixture was stirred at rt for 1 h, then was treated with 1 mL MeOH and evaporated to afford Intermediate 66.2, which was used in the following step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576098B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-ad36a6a4218e4c0ca9f1fb1149359bab |
| Source note | uspto-grants-2009_08 |