HRID2104972

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID7918

Acetic anhydride

C4H6O3

结构：CCOc1cc(CN(c2ccc(C(N)=NO)cc2)c2nc(Br)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)c(OC(C)C)c1

HCID86607935

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(CN(c2ccc(C(N)=NOC(C)=O)cc2)c2nc(Br)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)c(OC(C)C)c1

HCID86760938

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a suspension of Intermediate 66.1 in 20 mL EtOAc, was added 0.5 mL Ac2O. The reaction mixture was stirred at rt for 1 h, then was treated with 1 mL MeOH and evaporated to afford Intermediate 66.2, which was used in the following step without further purification.

WORKUP

后处理

customevaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad36a6a4218e4c0ca9f1fb1149359bab
来源数据集: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07576098B2
来源说明: uspto-grants-2009_08

反应 SMILES

[Br:1][C:2]1[N:3]=[C:4]([N:26]([CH2:37][C:38]2[CH:43]=[C:42]([O:44][CH2:45][CH3:46])[CH:41]=[C:40]([O:47][CH:48]([CH3:50])[CH3:49])[C:39]=2[F:51])[C:27]2[CH:36]=[CH:35][C:30]([C:31]([NH2:34])=[N:32][OH:33])=[CH:29][CH:28]=2)[N:5]([C:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=1.[CH3:52][C:53](OC(C)=O)=[O:54].CO>CCOC(C)=O>[Br:1][C:2]1[N:3]=[C:4]([N:26]([CH2:37][C:38]2[CH:43]=[C:42]([O:44][CH2:45][CH3:46])[CH:41]=[C:40]([O:47][CH:48]([CH3:50])[CH3:49])[C:39]=2[F:51])[C:27]2[CH:36]=[CH:35][C:30]([C:31]([NH2:34])=[N:32][O:33][C:53](=[O:54])[CH3:52])=[CH:29][CH:28]=2)[N:5]([C:7]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=1