HRID2104977

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57803952

未命名化合物

结构：CCOc1cc(CN(c2ccc(C#N)cc2)c2ccc3cc(Cl)ccc3n2)c(F)c(OC(C)C)c1

HCID68816823

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(CN(c2ccc(C#N)cc2)c2cc(C)c3cccc(C)c3n2)c(F)c(OC(C)C)c1

HCID68816898

未命名化合物

PROCEDURE

实验过程

According to the procedure for Intermediate 90.2, Intermediate 92.1 (100 mg, 0.424 mmol) afforded 97 mg of Intermediate 92.2 as an off-white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5f273850daea4249acf5f6c210944c82
来源数据集: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07576098B2
来源说明: uspto-grants-2009_08

反应 SMILES

ClC1C=C2C(=CC=1)N=C([N:12]([CH2:21][C:22]1[CH:27]=[C:26]([O:28][CH2:29][CH3:30])[CH:25]=[C:24]([O:31][CH:32]([CH3:34])[CH3:33])[C:23]=1[F:35])[C:13]1[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=1)C=C2.Br[C:37]1[CH:46]=[C:45]([CH3:47])[C:44]2[C:39](=[C:40]([CH3:48])[CH:41]=[CH:42][CH:43]=2)[N:38]=1>>[CH3:47][C:45]1[C:44]2[C:39](=[C:40]([CH3:48])[CH:41]=[CH:42][CH:43]=2)[N:38]=[C:37]([N:12]([CH2:21][C:22]2[CH:27]=[C:26]([O:28][CH2:29][CH3:30])[CH:25]=[C:24]([O:31][CH:32]([CH3:34])[CH3:33])[C:23]=2[F:35])[C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=2)[CH:46]=1