2-Bromo-4,8-dimethylquinoline → 4-((4,8-Dimethylquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile

HRID 2104977Notes

Reaction equation

HRID 2104977 reaction equation
ClC1C=C2C(=CC=1)N=C([N:12]([CH2:21][C:22]1[CH:27]=[C:26]([O:28][CH2:29][CH3:30])[CH:25]=[C:24]([O:31][CH:32]([CH3:34])[CH3:33])[C:23]=1[F:35])[C:13]1[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=1)C=C2.Br[C:37]1[CH:46]=[C:45]([CH3:47])[C:44]2[C:39](=[C:40]([CH3:48])[CH:41]=[CH:42][CH:43]=2)[N:38]=1>>[CH3:47][C:45]1[C:44]2[C:39](=[C:40]([CH3:48])[CH:41]=[CH:42][CH:43]=2)[N:38]=[C:37]([N:12]([CH2:21][C:22]2[CH:27]=[C:26]([O:28][CH2:29][CH3:30])[CH:25]=[C:24]([O:31][CH:32]([CH3:34])[CH3:33])[C:23]=2[F:35])[C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=2)[CH:46]=1

Participants

3

Reactant 2

HCID 578039522-Bromo-4,8-dimethylquinolineHCID 688168234-((6-Chloroquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile

Product 1

HCID 688168984-((4,8-Dimethylquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile

Procedure

According to the procedure for Intermediate 90.2, Intermediate 92.1 (100 mg, 0.424 mmol) afforded 97 mg of Intermediate 92.2 as an off-white solid.

Sources & evidence

ORD record
ord-5f273850daea4249acf5f6c210944c82
Source dataset
uspto-grants-2009_08
Patent number
US07576098B2

Reaction notes

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