Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104977Generated: October 30, 2026

2-Bromo-4,8-dimethylquinoline → 4-((4,8-Dimethylquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile

https://huagongshe.com/reaction/2104977

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-4,8-dimethylquinolineHCID 57803952—
Reactant4-((6-Chloroquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrileHCID 68816823—
Product4-((4,8-Dimethylquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrileHCID 68816898—

Reaction Steps

According to the procedure for Intermediate 90.2, Intermediate 92.1 (100 mg, 0.424 mmol) afforded 97 mg of Intermediate 92.2 as an off-white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576098B2
Source datasetuspto-grants-2009_08
ORD IDord-5f273850daea4249acf5f6c210944c82
Source noteuspto-grants-2009_08