Sodium Bicarbonate → HCID 15025355, compound

HRID 2105006Notes

Reaction equation

HRID 2105006 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([NH2:9])[C:3]=1[NH2:10].[C:11]([O-])(O)=O.[Na+]>C(O)=O.O>[CH3:1][C:2]1[C:3]2[N:10]=[CH:11][NH:9][C:4]=2[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 3613321(2-Amino-3,5-dimethylphenyl)amine

Product 1

HCID 15025355HCID 15025355, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 962WaterSolvent

Procedure

Intermediate 179.1 (275 mg) in 3 mL formic acid was irradiated in a microwave reactor at 150° C. for 5 min. The mixture was diluted with water, neutralized with sat. NaHCO3, then extracted with EtOAc (3×). The organic phase was washed with water and brine, dried (Na2SO4) and concentrated to afford 245 mg of Intermediate 179.2 as an orange solid.

Workup

  1. extractionextracted with EtOAc (3×)
  2. washThe organic phase was washed with water and brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-b12dffbbd6e747b3863617c0f5cb3dd2
Source dataset
uspto-grants-2009_08
Patent number
US07576098B2

Reaction notes

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