反应详情

温度

0 °C

To 5 mL acetic anhydride, was added 4-ethylaniline (0.50 mL, 4.02 mmol). The mixture was cooled to 0° C., then fuming red nitric acid (0.35 mL) was added, dropwise. The mixture was stirred at rt for 15 h, then was diluted with EtOAc. The organic phase was washed with sat. NaHCO3, water and brine, dried (Na2SO4) and concentrated to afford 555 mg of Intermediate 180.1, which was used in the following step without further purification.

1. additionwas added
2. washThe organic phase was washed with sat. NaHCO3, water and brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated