Hydrochloric Acid → 4-Ethyl-2-nitroaniline

HRID 2105008Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2105008
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9]C(=O)C)=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1)[CH3:2].Cl.C([O-])(O)=O.[Na+]>CCO.O.CCOC(C)=O>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1)[CH3:2]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 15919553N-(4-ethyl-2-nitrophenyl)acetamide

Produkt 1

HCID 2516744-Ethyl-2-nitroanilineAusbeute 96,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8857Ethyl AcetateLösungsmittelHCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

Intermediate 180.1 (413 mg) in EtOH/water/conc. HCl (3:4:1) was refluxed for 12 h, then was diluted with EtOAc. The aqueous layer was made basic with sat. NaHCO3, then the layers were separated. The organic phase was washed with water and brine, dried (Na2SO4) and concentrated to afford 317 mg of Intermediate 180.2 as a brown/orange solid.

Aufarbeitung

  1. customthe layers were separated
  2. washThe organic phase was washed with water and brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-e9a462264c7f42ab922091430bf90939
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07576098B2

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