反应详情

Intermediate 180.1 (413 mg) in EtOH/water/conc. HCl (3:4:1) was refluxed for 12 h, then was diluted with EtOAc. The aqueous layer was made basic with sat. NaHCO3, then the layers were separated. The organic phase was washed with water and brine, dried (Na2SO4) and concentrated to afford 317 mg of Intermediate 180.2 as a brown/orange solid.

1. customthe layers were separated
2. washThe organic phase was washed with water and brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated