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Hydrochloric Acid → 4-Ethyl-2-nitroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | N-(4-ethyl-2-nitrophenyl)acetamide | HCID 15919553 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | 4-Ethyl-2-nitroaniline | HCID 251674 | 96.2% |
反応手順
Intermediate 180.1 (413 mg) in EtOH/water/conc. HCl (3:4:1) was refluxed for 12 h, then was diluted with EtOAc. The aqueous layer was made basic with sat. NaHCO3, then the layers were separated. The organic phase was washed with water and brine, dried (Na2SO4) and concentrated to afford 317 mg of Intermediate 180.2 as a brown/orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07576098B2 |
| 出典データセット | uspto-grants-2009_08 |
| ORD ID | ord-e9a462264c7f42ab922091430bf90939 |
| 出典メモ | uspto-grants-2009_08 |