4-Bromo-1-methyl-1H-imidazole → 4-((4-bromo-1-methyl-1H-imidazol-2-yl)(5-ethyl-2-fluorophenyl)methylamino)benzonitrile
Reaction equation
[Br:1][C:2]1[N:3]=[C:4]([N:8]([CH2:18][C:19]2[CH:24]=[C:23](OCC)[CH:22]=[C:21](OC(C)C)[C:20]=2[F:32])[C:9]2[CH:17]=[CH:16][C:12]([C:13](N)=[NH:14])=[CH:11][CH:10]=2)[N:5]([CH3:7])[CH:6]=1.[CH2:33](C1C=CC(F)=C(C=1)C=CC1C=CC(C#N)=CC=1)[CH3:34].BrC1N=CN(C)C=1>>[Br:1][C:2]1[N:3]=[C:4]([N:8]([CH2:18][C:19]2[CH:24]=[C:23]([CH2:33][CH3:34])[CH:22]=[CH:21][C:20]=2[F:32])[C:9]2[CH:17]=[CH:16][C:12]([C:13]#[N:14])=[CH:11][CH:10]=2)[N:5]([CH3:7])[CH:6]=1Participants
4
Reactant 3
Product 1
Procedure
According to procedure for the preparation of Intermediate 259.1, Intermediate 262.1 and 4-bromo-1-methyl-1H-imidazole afforded Intermediate 262.2.
Sources & evidence
- ORD record
- ord-87a9c15e6a9e472eb060956317fb4eec
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07576098B2
Reaction notes
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