1-Methyl-3-phenyl-1H-1,2,4-triazole → (4-chloro-5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol

HRID 2105070Notes

Reaction equation

C(C1C=C(C(C2N(C)N=C(C3C=CC=CC=3)N=2)O)C=CC=1)C.[CH3:23][N:24]1[CH:28]=[N:27][C:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[N:25]1.[Cl:35][C:36]1[C:43]([CH2:44][CH3:45])=[CH:42][C:39]([CH:40]=[O:41])=[C:38]([F:46])[CH:37]=1>>[Cl:35][C:36]1[C:43]([CH2:44][CH3:45])=[CH:42][C:39]([CH:40]([C:28]2[N:24]([CH3:23])[N:25]=[C:26]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[N:27]=2)[OH:41])=[C:38]([F:46])[CH:37]=1

Participants

Reactant 3

HCID 108774081-Methyl-3-phenyl-1H-1,2,4-triazole

HCID 57803786(3-ethylphenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol

HCID 578038014-Chloro-5-ethyl-2-fluorobenzaldehyde

Product 1

HCID 57803972(4-chloro-5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanolYield 90.2%

Procedure

According to the procedure for Intermediate 370.2, 1-methyl-3-phenyl-1H-1,2,4-triazole (80 mg, 0.50 mmol) and Intermediate 390.2 (105 mg, 0.55 mmol) afforded 156 mg of Intermediate 390.3 as a white solid. LCMS 346.26 (M+H).

Sources & evidence

ORD record: ord-db0ba2d1c3714e839334fa6467518ef7
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576098B2

Reaction notes

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