1-Methyl-3-phenyl-1H-1,2,4-triazole → (4-chloro-5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol

Participants

Role	Name	HCID	Charge
Reactant	1-Methyl-3-phenyl-1H-1,2,4-triazole	HCID 10877408	—
Reactant	(3-ethylphenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol	HCID 57803786	—
Reactant	4-Chloro-5-ethyl-2-fluorobenzaldehyde	HCID 57803801	—
Product	(4-chloro-5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol	HCID 57803972	90.2%

Reaction Steps

According to the procedure for Intermediate 370.2, 1-methyl-3-phenyl-1H-1,2,4-triazole (80 mg, 0.50 mmol) and Intermediate 390.2 (105 mg, 0.55 mmol) afforded 156 mg of Intermediate 390.3 as a white solid. LCMS 346.26 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07576098B2
Source dataset	uspto-grants-2009_08
ORD ID	ord-db0ba2d1c3714e839334fa6467518ef7
Source note	uspto-grants-2009_08