1-Methyl-3-phenyl-1H-1,2,4-triazole → HCID 68814737, compound

HRID 2105073Notes

Reaction equation

HRID 2105073 reaction equation
C(C1C=C(C(C2N(C)N=C(C3C=CC=CC=3)N=2)O)C=CC=1)C.[CH3:23][N:24]1[CH:28]=[N:27][C:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[N:25]1.[Cl:35][C:36]1[C:43]([O:44][CH3:45])=[CH:42][C:39]([CH:40]=[O:41])=[C:38]([F:46])[CH:37]=1>>[Cl:35][C:36]1[C:43]([O:44][CH3:45])=[CH:42][C:39]([CH:40]([C:28]2[N:24]([CH3:23])[N:25]=[C:26]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[N:27]=2)[OH:41])=[C:38]([F:46])[CH:37]=1

Participants

4

Reactant 3

HCID 108774081-Methyl-3-phenyl-1H-1,2,4-triazoleHCID 149282684-Chloro-2-fluoro-5-methoxybenzaldehydeHCID 57803786(3-ethylphenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol

Product 1

HCID 68814737HCID 68814737, compoundYield 67.6%

Procedure

According to the procedure for Intermediate 370.2, 1-methyl-3-phenyl-1H-1,2,4-triazole (65 mg, 0.40 mmol) and Intermediate 392.1 (80 mg, 0.45 mmol) afforded 94 mg of Intermediate 392.2 as a white solid. LCMS 348.25 (M+H).

Sources & evidence

ORD record
ord-84dcd4a8e2a742a1b7f644c71458170e
Source dataset
uspto-grants-2009_08
Patent number
US07576098B2

Reaction notes

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