反应详情

Intermediate 416.3 (500 mg, 1.36 mmol) was heated in a solution of Acetone:Acetic Acid:H2O (2:1:1, 8 mL) at 125° C. for 30 min using a PC microwave. The reaction product was then concentrated and purified by flash chromatography (0 to 100% EtOAc/hexanes gradient) to afford 580 mg of Intermediate 416.4. LCMS (2 min gradient) RT=1.59 min, 326.31 (M+H)+.

1. concentrationThe reaction product was then concentrated
2. custompurified by flash chromatography (0 to 100% EtOAc/hexanes gradient)