HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-fluoro-5-(2-methyl-1,3-dioxolan-2-yl)phenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol → 1-(4-fluoro-3-(hydroxy(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methyl)phenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-fluoro-5-(2-methyl-1,3-dioxolan-2-yl)phenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol | HCID 57803748 | — |
| Solvent | Acetone Acetic Acid H2O | HCID 86607946 | — |
| Product | 1-(4-fluoro-3-(hydroxy(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methyl)phenyl)ethanone | HCID 57803645 | 131.1% |
Reaction Steps
Intermediate 416.3 (500 mg, 1.36 mmol) was heated in a solution of Acetone:Acetic Acid:H2O (2:1:1, 8 mL) at 125° C. for 30 min using a PC microwave. The reaction product was then concentrated and purified by flash chromatography (0 to 100% EtOAc/hexanes gradient) to afford 580 mg of Intermediate 416.4. LCMS (2 min gradient) RT=1.59 min, 326.31 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576098B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-c1fe8299016b4f30a4a15d40e30ca123 |
| Source note | uspto-grants-2009_08 |