p-Toluenesulfonic acid → HCID 178516922, compound

HRID 2105134Notes

Reaction equation

HRID 2105134 reaction equation
[NH2:1][C:2]1[NH:7][C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:5][C:4](=[O:16])[C:3]=1[S:17][CH2:18][C:19]([O:21]CC)=O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[C:10]1([CH2:9][S:8][C:6]2[NH:7][C:2]3[NH:1][C:19](=[O:21])[CH2:18][S:17][C:3]=3[C:4](=[O:16])[N:5]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 178473164HCID 178473164, compound

Product 1

HCID 178516922HCID 178516922, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of the product from step b) (0.30 g) in dry toluene (60 ml) was added p-toluene sulphonic acid (50 mg) and the solution heated under reflux for 11 hours. The resultant solid was collected by filtration, washed with ether and dried to give the subtitle compound as a colourless solid (0.290 g).

Workup

  1. temperaturethe solution heated
  2. temperatureunder reflux for 11 hours
  3. filtrationThe resultant solid was collected by filtration
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-bc4c43541f3d4f5bb2a09edd76af9ea7
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

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