Thionyl Chloride → 1-(Chloromethyl)-3-fluoro-2-methoxybenzene

HRID 2105154Notes

Reaction equation

HRID 2105154 reaction equation
[F:1][C:2]1[C:3]([O:10][CH3:11])=[C:4]([CH2:8]O)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22505951(3-Fluoro-2-methoxyphenyl)methanol

Product 1

HCID 225059631-(Chloromethyl)-3-fluoro-2-methoxybenzene

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-fluoro-2-methoxy-benzenemethanol (WO 20000419) (0.50 g) and thionyl chloride (0.47 ml) in dichloromethane (30 ml) was stirred for 2 hours then concentrated in-vacuo to give the subtitled compound, which was used directly in the next step.

Workup

  1. concentrationthen concentrated in-vacuo

Sources & evidence

ORD record
ord-73e71ab9b1744643bef29d9f7a878cb5
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

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