HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(Chloromethyl)-3-fluoro-2-methoxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (3-Fluoro-2-methoxyphenyl)methanol | HCID 22505951 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Chloromethyl)-3-fluoro-2-methoxybenzene | HCID 22505963 | — |
Reaction Steps
A solution of 3-fluoro-2-methoxy-benzenemethanol (WO 20000419) (0.50 g) and thionyl chloride (0.47 ml) in dichloromethane (30 ml) was stirred for 2 hours then concentrated in-vacuo to give the subtitled compound, which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579342B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-73e71ab9b1744643bef29d9f7a878cb5 |
| Source note | uspto-grants-2009_08 |