2-Fluorobenzyl mercaptan → 2-[[(2-Fluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

HRID 2105160Notes

Reaction equation

HRID 2105160 reaction equation
[F:1][C:2]1[C:7](F)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1)(=O)=O.FC1C=CC=CC=1CS>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1

Participants

3

Reactant 2

HCID 5221752-Fluorobenzyl mercaptanHCID 688171932-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

Product 1

HCID 688168852-[[(2-Fluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinoneYield 50.7%

Procedure

The titled compound (0.089 g) was prepared by the method of Example 13, step (c) using the product from Example 13, step (a) (0.20 g) and 2-fluorobenzylmercaptan (0.083 g).

Sources & evidence

ORD record
ord-296f41c11c91408e847c0ad1bbb3ae64
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

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