Thenyl mercaptan → 4-[[-2-Hydroxy-1-(hydroxymethyl)ethyl]amino]-2-[(2-thienylmethyl)thio]-7(8h)-pteridinone

HRID 2105162Notes

Reaction equation

HRID 2105162 reaction equation
F[C:2]1[C:7](F)=[CH:6]C=C[C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][CH:24]([CH2:27][OH:28])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:29])[NH:16][C:15]=2[N:14]=1)(=O)=O.[S:30]1C=CC=C1CS>>[OH:26][CH2:25][CH:24]([NH:23][C:21]1[C:20]2[N:19]=[CH:18][C:17](=[O:29])[NH:16][C:15]=2[N:14]=[C:13]([S:10][CH2:9][C:3]2[S:30][CH:6]=[CH:7][CH:2]=2)[N:22]=1)[CH2:27][OH:28]

Participants

3

Reactant 2

HCID 80408Thenyl mercaptanHCID 225059372-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[-2-hydroxy-1-hydroxymethylethyl]amino]-7(8H)-pteridinone

Product 1

HCID 225059754-[[-2-Hydroxy-1-(hydroxymethyl)ethyl]amino]-2-[(2-thienylmethyl)thio]-7(8h)-pteridinoneYield 53.5%

Procedure

The titled compound (0.075 g) was prepared by the method of Example 13, step (c) using the product from example 23, step (a) (0.21 g) and 2-thienylmethylmercaptan (0.05 g).

Sources & evidence

ORD record
ord-99da3c7b59a1408ab84172c2b655c82b
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

Loading…