2-[[(2,3-Difluorophenyl)methyl]thio]-4,5,6-pyrimidinetriamine → 4-Amino-2-[[(2,3-difluorophenyl)methyl]thio]-6-(trifluoromethyl)-7(8H)-pteridinone

HRID 2105167Notes

Reaction equation

HRID 2105167 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:11]1[N:16]=[C:15]([NH2:17])[C:14]([NH2:18])=[C:13]([NH2:19])[N:12]=1.[F:20][C:21]([F:28])([F:27])[C:22](=O)[C:23]([O-])=[O:24]>>[NH2:17][C:15]1[C:14]2[N:18]=[C:22]([C:21]([F:28])([F:27])[F:20])[C:23](=[O:24])[NH:19][C:13]=2[N:12]=[C:11]([S:10][CH2:9][C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])[N:16]=1

Participants

3

Reactant 2

HCID 222885032-[[(2,3-Difluorophenyl)methyl]thio]-4,5,6-pyrimidinetriamineHCID 22506014Trifluoropyruvate

Product 1

HCID 225060194-Amino-2-[[(2,3-difluorophenyl)methyl]thio]-6-(trifluoromethyl)-7(8H)-pteridinone

Procedure

The sub-titled compound was prepared from the product of Example 2, step (c) (5 g) and trifluoropyruvate (10 ml) using the method of Example 2, step (d).

Sources & evidence

ORD record
ord-94de552c9bc74a318c8cd84c5ac8d62f
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

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