4-Bromo-2-[[(2,3-difluorophenyl)methyl]thio]-6(trifluoromethyl)-7(8H)-pteridinone → 2-[[(2,3-Difluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-6-(trifluoromethyl)-7(8H)-pteridinone

HRID 2105169Notes

Reaction equation

HRID 2105169 reaction equation
Br[C:2]1[C:11]2[N:10]=[C:9]([C:12]([F:15])([F:14])[F:13])[C:8](=[O:16])[NH:7][C:6]=2[N:5]=[C:4]([S:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=2[F:26])[N:3]=1>N[C@@H](CO)C>[F:26][C:20]1[C:21]([F:25])=[CH:22][CH:23]=[CH:24][C:19]=1[CH2:18][S:17][C:4]1[N:3]=[C:2]([NH:10][C@H:9]([CH3:12])[CH2:8][OH:16])[C:11]2[N:10]=[C:9]([C:12]([F:14])([F:15])[F:13])[C:8](=[O:16])[NH:7][C:6]=2[N:5]=1

Participants

3

Reactant 1

HCID 225059584-Bromo-2-[[(2,3-difluorophenyl)methyl]thio]-6(trifluoromethyl)-7(8H)-pteridinone

Product 1

HCID 688156062-[[(2,3-Difluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-6-(trifluoromethyl)-7(8H)-pteridinone

Reagents, catalysts & solvents 1

HCID 80308(R)-(-)-2-Amino-1-propanolSolvent

Procedure

The titled compound was prepared from the product of example 37, step (b) (150 mg) and D-alaninol (100 μl) using the method of Example 2, step (f).

Sources & evidence

ORD record
ord-80c2f3030eaa42459afaa887d23c6915
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

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