反应详情

温度

5 °C

6-Chloronicotinoyl chloride (1.83 g, 10.4 mmol), in CH2Cl2 (20 ml) was added dropwise to a solution of 5,6-diamino-1,3-dipropyluracil (1.808 g, 8 mmol) in dry pyridine (8.2 ml) maintained at 5° C. The reaction was warmed to room temperature and stirred for an additional 3 hours. Water (50 ml) was added to quench the reaction. The solvent was evaporated to afford a dark colored oil. The oil was refluxed for 2 h in 2N NaOH (20 ml). After cooling, the pH was carefully adjusted to 7 with concentrated HCl. A solid formed and was collected and washed with water (20 ml), ether (20 ml) and chloroform(20 ml) to provide an off-white solid (1.9 g). The product was used in the next step without further purification.

1. temperatureThe reaction was warmed to room temperature
2. customto quench
3. customthe reaction
4. customThe solvent was evaporated
5. customto afford a dark colored oil
6. temperatureAfter cooling
7. customA solid formed
8. customwas collected
9. washwashed with water (20 ml), ether (20 ml) and chloroform(20 ml)