Pyrrolidine → HCID 11432010, compound

HRID 2105197Notes

Reaction equation

HRID 2105197 reaction equation
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([NH:7][C:8]2[CH:13]=[C:12]([CH2:14][CH2:15][CH:16]=CC)[N:11]=[C:10]([N:19]3[CH2:23][CH2:22][CH2:21][CH:20]3[C:24]3[O:28][N:27]=[C:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)[CH:25]=3)[N:9]=2)[CH:3]=1.[NH:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1>>[N:35]1([CH2:16][CH2:15][CH2:14][C:12]2[N:11]=[C:10]([N:19]3[CH2:23][CH2:22][CH2:21][CH:20]3[C:24]3[O:28][N:27]=[C:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)[CH:25]=3)[N:9]=[C:8]([NH:7][C:4]3[CH:3]=[C:2]([CH3:1])[NH:6][N:5]=3)[CH:13]=2)[CH2:39][CH2:38][CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 68815296HCID 68815296, compound

Product 1

HCID 11432010HCID 11432010, compound

Procedure

Example 44 was prepared by an analogous method to that described in Example 43 starting from 4-(5-methyl-1H-pyrazol-3-ylamino)-6-(pent-3-en-1-yl)-2-[2-{3-(pyrid-2-yl)isoxazol-5-yl}pyrrolidin-1-yl]pyrimidine (Example 34) and pyrrolidine.

Workup

  1. customExample 44 was prepared by an analogous method to

Sources & evidence

ORD record
ord-0f209eb42ac6422cb98077b8f4b3da05
Source dataset
uspto-grants-2009_08
Patent number
US07579349B2

Reaction notes

Loading…