Piperazine → HCID 68813202, compound

HRID 2105218Notes

Reaction equation

HRID 2105218 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH:9]2[C:13]2[O:17][N:16]=[C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[CH:14]=2)[N:5]=[C:4]([NH:24][C:25]2[CH:29]=[C:28]([CH3:30])[NH:27][N:26]=2)[CH:3]=1.[NH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[N:31]1([C:2]2[N:7]=[C:6]([N:8]3[CH2:12][CH2:11][CH2:10][CH:9]3[C:13]3[O:17][N:16]=[C:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=4)[CH:14]=3)[N:5]=[C:4]([NH:24][C:25]3[CH:29]=[C:28]([CH3:30])[NH:27][N:26]=3)[CH:3]=2)[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 11281654HCID 11281654, compound

Product 1

HCID 68813202HCID 68813202, compound

Procedure

Starting materials: 6-chloro-2-{2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidin-1-yl}-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidine (Example 17) and piperazine. Yield: 204 mg, 73% as a white powder.

Sources & evidence

ORD record
ord-cd8fca57f3e24f3d8d5cea9c717fc107
Source dataset
uspto-grants-2009_08
Patent number
US07579349B2

Reaction notes

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