Trifluoroacetic acid → 2-[3-(Pyrid-2-yl)isoxazol-5-yl]pyrrolidine-1-carboximidamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

TFA (30 ml) was added to a cooled solution of N,N′-di(tert-butyloxycarbonyl)-2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidine-1-carboximidamide (Method 39) in DCM (150 ml) at 0° C. The mixture was stirred 0° C. for one hour, allowed to warm to ambient temperature and stirred for a further 18 hours. The volatiles were removed by evaporation and the residue triturated from DCM/ether/hexane. The product was collected by filtration to give the title compound (2.2 g, >100%).

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