Trifluoroacetic acid → HCID 59643717, compound

HRID 2105273Notes

Reaction equation

HRID 2105273 reaction equation
[Cl:1][C:2]1[C:3]([OH:34])=[C:4]([S:9]([NH:12][C:13]2[CH:27]=[CH:26][CH:25]=[C:24]([N:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)[C:14]=2[CH2:15][NH:16]C(=O)OC(C)(C)C)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(O)(C(F)(F)F)=O>ClCCl>[NH2:16][CH2:15][C:14]1[C:24]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:25][CH:26]=[CH:27][C:13]=1[NH:12][S:9]([C:4]1[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[C:3]=1[OH:34])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59643727HCID 59643727, compound

Product 1

HCID 59643717HCID 59643717, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 47 (75 mg) in dichloromethane (5 mL) was added TFA (0.5 mL). The solution was stirred overnight. Followed by usual workup. The title compound was obtained as an off-white solid (35 mg).

Sources & evidence

ORD record
ord-405388c1d3934ba2923aec477038d514
Source dataset
uspto-grants-2009_08
Patent number
US07579340B2

Reaction notes

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