Triphenylphosphine → HCID 16679024, compound

HRID 2105419Notes

Reaction equation

HRID 2105419 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]3[CH2:11][CH2:12][CH2:13][N:14]([CH2:17][CH2:18][O:19][CH3:20])[C:15](=[O:16])[C:6]3=[CH:5][C:4]=2[CH:3]=1.[CH:21]([N:24]1[CH2:29][CH2:28][CH:27](O)[CH2:26][CH2:25]1)([CH3:23])[CH3:22].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)(C)C)=O)=O)(C)C>>[CH:21]([N:24]1[CH2:29][CH2:28][CH:27]([O:1][C:2]2[CH:10]=[CH:9][C:8]3[N:7]4[CH2:11][CH2:12][CH2:13][N:14]([CH2:17][CH2:18][O:19][CH3:20])[C:15](=[O:16])[C:6]4=[CH:5][C:4]=3[CH:3]=2)[CH2:26][CH2:25]1)([CH3:23])[CH3:22]

Participants

5

Reactant 4

HCID 11776TriphenylphosphineHCID 796811-Isopropylpiperidin-4-olHCID 6034084Di-tert-butyl diazene-1,2-dicarboxylateHCID 68465391HCID 68465391, compound

Product 1

HCID 16679024HCID 16679024, compoundYield 2%

Procedure

The title compound was synthesized in analogy to example 1, from 9-hydroxy-2-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one, 1-isopropyl-piperidin-4-ol (commercially available), triphenylphosphine and di-tert-butylazodicarboxylate, to give the desired product as a light yellow oil (2%).

Sources & evidence

ORD record
ord-93205cf54d344378bf1b461d8bdff6dc
Source dataset
uspto-grants-2009_08
Patent number
US07579351B2

Reaction notes

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