(2S)-2-methylpyrrolidine → 7-[3-((S)-2-Methyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

HRID 2105428Notes

Reaction equation

HRID 2105428 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:18]=[C:17]2[C:9]([N:10]3[C:15](=[CH:16]2)[C:14](=[O:19])[NH:13][CH2:12][CH2:11]3)=[N:8][CH:7]=1.[CH3:20][C@H:21]1[CH2:25][CH2:24][CH2:23][NH:22]1>>[CH3:20][C@H:21]1[CH2:25][CH2:24][CH2:23][N:22]1[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:18]=[C:17]2[C:9]([N:10]3[C:15](=[CH:16]2)[C:14](=[O:19])[NH:13][CH2:12][CH2:11]3)=[N:8][CH:7]=1

Participants

3

Reactant 2

HCID 6999702(2S)-2-methylpyrrolidineHCID 684627297-(3-chloro-propoxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

Product 1

HCID 166790307-[3-((S)-2-Methyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-oneYield 19%

Procedure

The title compound was synthesized in analogy to example 2, from 7-(3-chloro-propoxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one and (S)-2-methylpyrrolidine (commercially available), to give the desired product as a colorless solid (19%).

Sources & evidence

ORD record
ord-7845984041ff4887bc6e9d0b456bf44d
Source dataset
uspto-grants-2009_08
Patent number
US07579351B2

Reaction notes

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