1-Bromo-3-chloropropane → 7-(3-chloro-propoxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

HRID 2105429Notes

Reaction equation

HRID 2105429 reaction equation
[OH:1][C:2]1[CH:14]=[C:13]2[C:5]([N:6]3[C:11](=[CH:12]2)[C:10](=[O:15])[NH:9][CH2:8][CH2:7]3)=[N:4][CH:3]=1.Br[CH2:17][CH2:18][CH2:19][Cl:20]>>[Cl:20][CH2:19][CH2:18][CH2:17][O:1][C:2]1[CH:14]=[C:13]2[C:5]([N:6]3[C:11](=[CH:12]2)[C:10](=[O:15])[NH:9][CH2:8][CH2:7]3)=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 684640317-hydroxy-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

Product 1

HCID 684627297-(3-chloro-propoxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-oneYield 80%

Procedure

The title compound was synthesized in analogy to example 2, intermediate, from 7-hydroxy-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one (example 84, intermediate a) and 1-bromo-3-chloropropane, to give the desired product as a light yellow solid (80%).

Sources & evidence

ORD record
ord-0943760d2d71451cb76c1188d0d02866
Source dataset
uspto-grants-2009_08
Patent number
US07579351B2

Reaction notes

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