HCID 68424210, compound → HCID 86612932, compound

HRID 2105439Notes

Reaction equation

HRID 2105439 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[CH:17]=[C:16]([CH2:18][OH:19])[NH:15][C:12]2=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[CH:17]=[C:16]([CH:18]=[O:19])[NH:15][C:12]2=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 68424210HCID 68424210, compound

Product 1

HCID 86612932HCID 86612932, compoundYield 74%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

The suspension of 0.3 g (1.2 mmol) (5-benzyloxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-methanol and 0.82 g (9.4 mmol) manganese dioxide in 15 ml dichloromethane was stirred 3 h at room temperature. After filtration over dicalite speed plus® (Aldrich) the solvent was evaporated to give 0.22 g (74%) of the desired compound as a light brown solid.

Workup

  1. filtrationAfter filtration over dicalite speed plus® (Aldrich) the solvent
  2. customwas evaporated

Sources & evidence

ORD record
ord-7474e6cc68b5494ba823d3ab7d3dd892
Source dataset
uspto-grants-2009_08
Patent number
US07579351B2

Reaction notes

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