反应详情

A solution of N-(4-chloroquinolin-3-yl)-2-methylpropanamide (6.0 g, 24 mmol), O-methylhydroxylamine hydrochloride (2.5 g, 0.030 mol), and ethanol (75 mL) was heated at reflux for five hours, allowed to cool to room temperature, stirred overnight, and concentrated under reduced pressure. The residue was dissolved in dichloromethane (100 mL), and the solution was washed with saturated aqueous sodium carbonate (2×50 mL) dried over potassium carbonate, filtered, and concentrated under reduced pressure to provide 4.9 g of 2-isopropyl-1-methoxy-1H-imidazo[4,5-c]quinoline as a dark oil.

1. temperatureat reflux for five hours
2. concentrationconcentrated under reduced pressure
3. dissolutionThe residue was dissolved in dichloromethane (100 mL)
4. washthe solution was washed with saturated aqueous sodium carbonate (2×50 mL)
5. dry with materialdried over potassium carbonate
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure