反应详情

The method of Part B of Example 25 was used to treat N-(4-chloroquinolin-3-yl)acetamide (2.9 g, 13 mmol) with O-(2-phenoxyethyl)hydroxylamine hydrochloride (2.5 g, 13 mmol) in lieu of O-methylhydroxylamine hydrochloride with the modification that the reaction was heated at reflux overnight. 2-Methyl-1-(2-phenoxyethoxy)-1H-imidazo[4,5-c]quinoline (2.7 g) was obtained as a dark oil.

1. temperaturewas heated
2. temperatureat reflux overnight