Glycerol → HCID 15975762, compound

HRID 2105633Notes

Reaction equation

HRID 2105633 reaction equation
OCC(CO)O.[O:7]=[C:8]([CH3:20])[CH2:9][CH2:10][CH2:11][CH2:12][C@@H:13]([CH2:17][CH2:18][CH3:19])[C:14]([OH:16])=[O:15]>O>[O:7]=[C:8]([CH3:20])[CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([CH2:17][CH2:18][CH3:19])[C:14]([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 753GlycerolHCID 11424200(2R)-7-oxo-2-propyloctanoic acid

Product 1

HCID 15975762HCID 15975762, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Gelatin (20 kg) and concentrated glycerin (6 kg) were admixed in the presence of purified water (20 kg) at 70° C. to give homogeneous solution. (2R)-7-oxo-2-propyloctanoic acid (0.9 kg) was injected into soft capsule filling machine (rotary-type soft capsule filling machine (TYPE-H1 manufactured by KAMATA CO., LTD.)) to give wet soft capsules each containing (2S)-7-oxo-2-propyloctanoic acid. The obtained wet soft capsules were dried by tumble-dry and rack-dry sequentially, thereby obtaining above captioned soft capsules (2200 capsules) each containing 300 mg of (2S)-7-oxo-2-propyloctanoic acid.

Workup

  1. customto give homogeneous solution

Sources & evidence

ORD record
ord-e0d20327d7bf4f4c8113debd3dccd7f9
Source dataset
uspto-grants-2009_08
Patent number
US07579375B2

Reaction notes

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