HCID 67078566, compound → HCID 18767683, compound

HRID 2105644Notes

Reaction equation

HRID 2105644 reaction equation
COC(=O)[NH:4][C:5]12[CH2:12][CH2:11][C:8]([C:13]3[NH:21][C:20]4[C:19](=[O:22])[N:18]([CH2:23][CH2:24][CH3:25])[C:17](=[O:26])[N:16]([CH2:27][CH2:28][CH3:29])[C:15]=4[N:14]=3)([CH2:9][CH2:10]1)[CH2:7][CH2:6]2>Cl>[NH2:4][C:5]12[CH2:12][CH2:11][C:8]([C:13]3[NH:21][C:20]4[C:19](=[O:22])[N:18]([CH2:23][CH2:24][CH3:25])[C:17](=[O:26])[N:16]([CH2:27][CH2:28][CH3:29])[C:15]=4[N:14]=3)([CH2:9][CH2:10]1)[CH2:7][CH2:6]2

Participants

3

Reactant 1

HCID 67078566HCID 67078566, compound

Product 1

HCID 18767683HCID 18767683, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-carbamic acid methyl ester (Example 13d) (8.3 gm, 20 mmol) was refluxed in 40 ml of conc. HCl for 3 h. The reaction mixture was concentrated in vacuo to a solid residue which was triturated in acetonitrile to afford 5.8 gm (77%) as a white solid (MH+=360.02)

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo to a solid residue which
  2. customwas triturated in acetonitrile
  3. customto afford 5.8 gm (77%) as a white solid (MH+=360.02)

Sources & evidence

ORD record
ord-63f9c046350741469cdafc2a1ad9e2cb
Source dataset
uspto-grants-2009_08
Patent number
US07579354B2

Reaction notes

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