Phenethylamine → HCID 58999022, compound

HRID 2105787Notes

Reaction equation

HRID 2105787 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[O:20][CH3:21])=O.[CH2:22]([NH2:30])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[CH:31]1([NH2:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([NH:37][C:3]([C:4]2[CH:10]=[C:11]([C:13]3[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=3[O:20][CH3:21])[N:30]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:5]=2[CH3:6])=[O:2])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

5

Reactant 4

HCID 1001PhenethylamineHCID 7757Methyl acetoacetateHCID 7965CyclohexylamineHCID 27569852-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

Product 1

HCID 58999022HCID 58999022, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(5-fluoro-2-methoxy-phenyl)-ethanone as compound of formula S, phenethylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 435.5 (M+H)+.

Sources & evidence

ORD record
ord-debb21b9704e4e79ac552606874de0b9
Source dataset
uspto-grants-2009_08
Patent number
US07579369B2

Reaction notes

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