Phenethylamine → HCID 58999051, compound

HRID 2105793Notes

Reaction equation

C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[O:20][CH3:21])=O.[CH2:22]([NH2:30])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[C@@H:31]([NH2:35])([CH2:33][CH3:34])[CH3:32]>>[C@@H:31]([NH:35][C:3]([C:4]1[CH:10]=[C:11]([C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=2[O:20][CH3:21])[N:30]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:5]=1[CH3:6])=[O:2])([CH2:33][CH3:34])[CH3:32]

Participants

Reactant 4

HCID 1001Phenethylamine

HCID 7757Methyl acetoacetate

HCID 27569852-Bromo-1-(5-fluoro-2-methoxyphenyl)ethanone

HCID 67137532-Butanamine, (S)-

Product 1

HCID 58999051HCID 58999051, compound

Procedure

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(5-fluoro-2-methoxy-phenyl)-ethanone as compound of formula S, phenethylamine as R3—(CH2)m—NH2 and (S)-sec-butylamine as R1R2NH, MS (ISP) 409.4 (M+H)+.

Sources & evidence

ORD record: ord-5b53733b4adc411985e2ba8ac6faa82c
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579369B2

Reaction notes

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