Chloroacetyl chloride → N-(2-Methoxyethyl)-1-piperazineacetamide

HRID 2105868Notes

Reaction equation

C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.ClC[C:16](Cl)=[O:17].[CH3:19][O:20][CH2:21][CH2:22][NH2:23]>>[CH3:19][O:20][CH2:21][CH2:22][NH:23][C:16](=[O:17])[CH2:6][N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

Participants

Reactant 3

HCID 6577Chloroacetyl chloride

HCID 80182-Methoxyethylamine

HCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 7131115N-(2-Methoxyethyl)-1-piperazineacetamide

Procedure

The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and 2-methoxyethylamine in an analogous manner as described in example 21.

Sources & evidence

ORD record: ord-82e48d50ae9747489aa72bab656d5f5a
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579368B2

Reaction notes

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