Hydrochloric Acid → 1-(2-Methanesulfonylethyl)piperazine dihydrochloride

HRID 2105870Notes

Reaction equation

HRID 2105870 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[ClH:1].[CH3:20][S:17]([CH2:16][CH2:15][N:12]1[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]1)(=[O:18])=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66649624tert-Butyl 4-(2-(methylsulfonyl)ethyl)piperazine-1-carboxylate

Product 1

HCID 177498851-(2-Methanesulfonylethyl)piperazine dihydrochlorideYield 99.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Hydrochloric acid (42 mL, 168 mmol, 4 M in 1,4-dioxane) was added to a cooled solution of 1-tert-butyloxycarbonyl-4-(2-methanesulfonylethyl)piperazine (2.29 g, 7.8 mmol) in 1,4-dioxane (42 mL). The mixture was stirred at room temperature overnight then concentrated to give 1-(2-methanesulfonylethyl)piperazine bishydrochloride as a white solid (2.05 g).

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-d10b27eae5c94da68a4da641513280fe
Source dataset
uspto-grants-2009_08
Patent number
US07579368B2

Reaction notes

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