Potassium Carbonate → HCID 68814273, compound

HRID 2105942Notes

Reaction equation

HRID 2105942 reaction equation
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1([OH:18])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:26][CH2:27][CH2:28][F:29]>C(#N)C>[F:29][CH2:28][CH2:27][CH2:26][N:15]1[CH2:16][CH2:17][C:12]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([C:8]([F:10])([F:11])[F:9])[C:2]=2[F:1])([OH:18])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 67699Propane, 1-bromo-3-fluoro-HCID 68813278HCID 68813278, compound

Product 1

HCID 68814273HCID 68814273, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 2: 4-[2-fluoro-3-(trifluoromethyl)phenyl]piperidin-4-ol (0.02 g, 0.076 mmol), acetonitrile (2 ml), potassium carbonate (0.02 g, 0.14 mmol), 1-bromo-3-fluoropropane (0.010 ml, 0.082 mmol). MS m/z (relative intensity, 70 eV) 323 (M+, 2), 276 (34), 191 (15), 116 (17), 42 (bp).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-b18352790c6a44b891bfb7c601c9a4b6
Source dataset
uspto-grants-2009_08
Patent number
US07579474B2

Reaction notes

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