1-Bromo-2-methylpropane → HCID 68817292, compound

HRID 2105945Notes

Reaction equation

HRID 2105945 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.C(=O)([O-])[O-:16].[K+].[K+].Br[CH2:22][CH:23]([CH3:25])[CH3:24]>C(#N)C>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1([OH:16])[CH2:14][CH2:13][N:12]([CH2:22][CH:23]([CH3:25])[CH3:24])[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 11430Potassium CarbonateHCID 17895683HCID 17895683, compound

Product 1

HCID 68817292HCID 68817292, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 2: 4-(2,3-dichlorophenyl)piperidine (0.02 g, 0.081 mmol), acetonitrile (2 ml), potassium carbonate (0.02 g, 0.14 mmol), 1-bromo-2-methylpropane (0.009 ml, 0.082 mmol). MS m/z (relative intensity, 70 eV) 303 (M+, 1), 302 (M+, 2), 260 (63), 258 (bp), 242 (19), 240 (29).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-68c1ea64af574a368d3fe053d882118c
Source dataset
uspto-grants-2009_08
Patent number
US07579474B2

Reaction notes

Loading…